Dr. Hanna K. Sanoff of the UNC Lineberger Comprehensive Cancer Center called the monoclonal antibody used to treat the patients, dostarlimab, "remarkable," but nevertheless encouraged cautious optimism "until the results can be replicated in a larger and more diverse population."

The impressive data are the result of a small cancer treatment trial led by doctors at Memorial Sloan Kettering Cancer Center in New York City and backed by the pharmaceutical company GlaxoSmithKline. The results of the 18-person trial were first outlined Sunday in the New England Journal of Medicine.

From the study:

We initiated a prospective phase 2 study in which single-agent dostarlimab, an anti–PD-1 monoclonal antibody, was administered every 3 weeks for 6 months in patients with mismatch repair–deficient stage II or III rectal adenocarcinoma. This treatment was to be followed by standard chemoradiotherapy and surgery.

As The Times described it, the antibody treatment "unmasks cancer cells, allowing the immune system to identify and destroy them." After completing the regimen, none of the trial participants had to seek further cancer treatment because they all had "a clinical complete response, with no evidence of tumor on magnetic resonance imaging," according to the authors of the study.

"At the time of this report, no patients had received chemoradiotherapy or undergone surgery, and no cases of progression or recurrence had been reported during follow-up (range, 6 to 25 months)," the doctors explained. "No adverse events of grade 3 or higher have been reported"... Subscribe for free to Breaking Christian News here

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